Clinical Study on CI-581, a Phencyclidine Derivative
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چکیده
منابع مشابه
Clinical trial of ketamine (CI-581): a preliminary report.
PHENCI'CLWL\TE (SERNYL) is a potent anaesthetic agent producing good analgesia and complete sensory dissociation. 1,2 Because of the occurrence of postoperative confusional states and hallucination in a proportion of cases, and also purposeless movements during its use, ~ it was withdrawn from the market by the manufacturers. Ketamine, or cI-581, as it is often referred to, is a derivative of p...
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THE A~CTIC nECXONS have been made accessible by the airplane, and commercial and military interests have brought our civilization into the North. The resulting rapid change in the living conditions of the Eskimos has produced, among other problems, a high rate of dental decay in children. Lack of dental hygiene combined with the ready supply of soft drinks and concentrated carbohydrates is the ...
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We examined the effects of CI-973 (supplied by Parke-Davis) on several human leukemia cell lines and a Chinese hamster ovary (CHO) line and their drug-resistant counterparts. The cell lines used were HL-60, HL-60/mAMSA, HL-60/DOX, KBM3, KBM3/mAMSA 6, KBM3/mAMSA 6(85), CHO, and CHO/AC-7. DOX, mAMSA, and AC-7 indicate resistance to doxorubicin, amsacrine, or l-/3-t>-arabinofuranosylcytosine, resp...
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We examined the effects of CI-973 (supplied by Parke-Davis) on several human leukemia cell lines and a Chinese hamster ovary (CHO) line and their drug-resistant counterparts. The cell lines used were HL-60, HL-60/mAMSA, HL-60/DOX, KBM3, KBM3/mAMSA 6, KBM3/mAMSA 6(85), CHO, and CHO/AC-7. DOX, mAMSA, and AC-7 indicate resistance to doxorubicin, amsacrine, or 1-beta-D-arabinofuranosylcytosine, res...
متن کاملCardiovascular effects of 2-(O-chlorophenyl)-2-methylaminocyclohexanone (CI-581) in rats.
2-(0-chlorophenyl)-2-methylaminocyclohexanone (CI-581), a derivative of phencyclidine, was shown to depress the cardiovascular system in conscious rats and in rats anaesthetized with pentobarbitone and urethane. In pithed animals, however, there was a substantial rise in blood pressure, suggesting that CI-581 may act on the central cardiovascular regulatory mechanisms. The pressor response to C...
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ژورنال
عنوان ژورنال: The Tohoku Journal of Experimental Medicine
سال: 1967
ISSN: 0040-8727,1349-3329
DOI: 10.1620/tjem.93.39